Presented at the 2013 AAPM Annual Meeting « Back

The Comparison of Effects of Intraarticular Steroid Versus Nonsteroid Tenoxicam Injections in Patients with Knee Osteoarthritis

Omer Faruk Savluk, dromersavluk@hotmail.com¹, Ayse Baysal², Mesut Erbas³, Huseyin Toman⁴, (1) Yahyali State Hospital, Kayseri, Turkey, (2) Kartal Kosuyolu Research and Training Hospital, Istanbul, Turkey, (3) Bunyan Government Hospital, Kayseri, Turkey, (4) Canakkale University Hospital, Canakkale, Turkey

Introduction: The effectiveness of application of intraarticular (IA) steroid versus tenoxicam, nonsteroid anti-inflammatory drug for patients with knee osteoarthritis is compared by various pain and physical activity assessment tests before and after treatment during a period of six months. Methods: Two hundred patients were enrolled in a prospective, randomized study after Ethical Committee approval. In Group 1 (n=100), IA triamcinolone at dose of 40 mg and in Group 2 (n=100), IA tenoxicam at dose of 20 mg was administered to patients. Pain and physical activity were assessed using (VAS), WOMAC and Laquesne tests before treatment, first week, first, third and sixth months after treatment. Student's t and Friedman tests were used. Results: Lower VAS scores in Group 1 was observed in comparison to Group 2 in the first week and first month after treatment (p<0.001). Lower WOMAC pain, stiffness, physical function and Laquesne index scores were observed in Group 1 in comparison to Group 2 in the first week after treatment (p<0.001). No differences were observed in other follow-up visits (p>0.05). Discussion and Conclusion: In patients with knee osteoarthritis, application of IA corticosteroid or nonsteroid anti-inflammatory therapies decrease pain intensity and increase physical activity within one week after treatment and this effect continues for a six months of duration. Keywords: Pain, osteoarthrit, knee, intra-articular steroid, nonsteroid anti-inflammatory drugs, Visual Analog Scale, WOMAC test, Laquesne index score. References: 1) Peyron Jg.The epidemiyology of osteoartritis. In:Moskowitz RW,Howell DS,Goldberg VM,Mankin HJ,editors.Ch1 in osteoartritis, diagnosis and management. Philadelphia: W.B.Saunders;1984.P.9-27. 2) Ersöz M,Ergün S.Diz osteoartritli olgularda diz eklem kompartmanlarinin Kellgren-Lawrence sistemiyle incelenmesi.Türk Fiz TipRehab Derg2001;47:5 3) Recommendation for the medical management of osteoarthritis of the hip and knee:2000 update, American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum 2000;43:1905-15.

Funding: None

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