Clinical Reference Resources
Drug Metabolism Chart
by Robert Barkin, PharmD, MBA, FCP
Many opioid and other analgesic agents are subject to metabolism and elimination via a variety of hepatic enzymes. These elimination pathways may be directly related to impaired or excessive pharmacologic responses, depending on the coadministration of other medications capable of inducing, inhibiting, or competing for access to these enzymes creating significant drug interactions. The following tables identify many of the important pathways involved in analgesic metabolism and may be useful references for determining drug interactions.
MEDLINEplus - Online Library of 17 Million Biomedical Articles
PubMed is a service of the U.S. National Library of Medicine at the National Institues of Health that includes over 17 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources.
Latest News
FDA Halts Unapproved Prescription Narcotic Drugs
(4/1/09) Nine Companies were told to stop marketing unapproved narcotic drugs that are widely used to treat pain.
> Read More
New! Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain
(3/1/09) This expert panel concluded that chronic opioid therapy can be an effective therapy for carefully selected and monitored patients with chronic noncancer pain...
> Read More
AAPM's award-winning publications are devoted to the advancement of
pain management, education and research.